Cuifang Kuang

Physics-informed single-frame end-to-end learning for denoising and background removal in fluorescence imaging

Fluorescence microscopy is often limited by low signal-to-noise ratios arising from the finite number of detected photons and by an out-of-focus background that obscures structural details. Here, we introduce a physics-informed end-to-end learning framework that enables denoising...

Hybrid iterative ptychographic super-resolution microscopy

Abstract By utilizing an array detector to replace the single-element detector in confocal microscopy, Image Scanning Microscopy (ISM) overcomes the inherent trade-off between resolution and signal-to-noise ratio (SNR), thereby enhancing its ability to resolve sub-diffraction fea...