Cristina Fornaguera

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Transcription factors (TFs) are often considered undruggable due to their structural complexity. mRNA technologies can overcome this therapeutic limitation by enabling dynamic protein replacement therapies. Here, we explore the TF activity of LCOR (Ligand‐dependent corepressor),...

Computationally Guided Engineering of Short Peptides for Targeted RNA-Loaded pBAE Nanoparticles

Abstract Nanoparticles encapsulating therapeutic RNA have emerged as a transformative strategy in precision medicine, enabling a wide range of applications such as gene therapy for rare diseases, the silencing of toxic gene products, and the mobilization of the immune system to i...