Craig Simmons

Shear Stress Regulates C-type Natriuretic Peptide Gene Expression by Valvular Endothelial Cells in a Sex-Dependent Manner

Abstract Aortic valve disease initiates on the fibrosa (aorta-facing) side of the valve leaflets, whereas the ventricularis side is disease-protected. Spatially predictable disease correlates with side-specific hemodynamics and gene expression: fibrosa-side valvular endothelial c...