Cory E. Goldstein

Ethical and Methodological Features of Cluster Randomized Trials in Critical Care Settings: A Systematic Review

OBJECTIVES: Cluster randomized trials (CRTs) are useful for evaluating system-level interventions in critical care but raise complex ethical and methodological issues that are amplified in this setting. We aimed to describe ethical and methodological features of CRTs in critical...

Reporting of justifications for withholding established effective interventions in randomised placebo-controlled trials: a systematic review

Randomised-controlled-trials (RCTs) are crucial for assessing the efficacy of new treatments. Some RCTs are placebo-controlled, which is uncontroversial when there is no established effective intervention or when a placebo is added to one. However, withholding an established effe...