Connie E. Briggs

Epstein–Barr Virus, Varicella-Zoster Virus, and Multiple Sclerosis: A Mechanistic Hypothesis

Epstein–Barr virus (EBV), a major risk factor for multiple sclerosis (MS), cannot alone explain MS susceptibility or characteristic central nervous system (CNS) lesion patterns. Here, a two-hit mechanism is proposed whereby prior infection with a high-risk varicella-zoster virus...