Conggang Li

Monofluoromethylphenylalanine: A Sensitive 19F Probe for Protein Conformational Dynamics In Vitro and in Cells

Abstract The combination of site-specific incorporation of 19F-labeled unnatural amino acids (UAAs) and 19F nuclear magnetic resonance (NMR) spectroscopy is a powerful strategy for investigating protein structure, dynamics, and interactions. However, commonly used 19F-containing...

Recognition Mechanism of Serotonin by a G‐Quadruplex–Duplex Hybrid Aptamer

ABSTRACT Serotonin is a key neurotransmitter, and aptamer‐based tools using the 44‐nt Apt44 have been successfully developed for its in vitro and in vivo detection. Nevertheless, the structural basis of recognition by this aptamer remains unclear. Here, we report high‐resolution...