Cong Su

Enzymatic Ligation-Enhanced Catalytic Hairpin Assemblyfor Accelerated Kinetics with Restricted Leakage

Abstract Enthalpy-driven catalytic hairpin assembly (CHA) suffers from an inherent trade-off, wherein enhanced reaction kinetics is inevitably accompanied by elevated nonspecific background. Catalytic hairpin assembly-and-cyclization (CHAC) integrates CHA with enzymatic ligation,...