Colleen L. Lau

Seroprevalence of 17 pathogens from an integrated national serosurvey in Niue

Integrated serosurveillance (ISS), using multiplex bead assays to measure antibodies to multiple pathogens, can provide insights into population immunity and pathogen exposure. We estimated seroprevalence for neglected tropical diseases (NTDs), arboviruses, vaccine-preventable di...

Evaluating the impact of triple-drug mass drug administration using human and mosquito-based indicators of lymphatic filariasis in Samoa, 2019 – 2024

Background For lymphatic filariasis (LF) elimination, the World Health Organization recommends multiple rounds of mass drug administration (MDA) to interrupt transmission. While LF antigen (Ag) is routinely used to monitor progress, recent evidence suggests more time-sensitive in...

Immune correlates of protection are exposure-dependent: evidence from the Dominican Republic

Immune protection against infection is often treated as a fixed property of a person’s immune response. But infection risk also depends on the number of infectious contacts a person experiences, which generally increases as community transmission rises. This matters for vaccine e...