Colin L. Sweeney

MATRIN3 deficiency in human cells triggers an autoinflammatory response via cGAS–STING activation

MATRIN3 (MATR3) is a broadly expressed nuclear RNA-binding protein. However, the mechanisms by which MATR3 maintains human cellular health remain poorly understood. In this study, we employed gene editing to model MATR3 deficiency in human induced pluripotent stem cells (iPSCs) a...