Clémence Frioux

Temporal strain-resolved metagenomics associates IBD dysbiosis with gastrointestinal inflammation

Abstract The gut microbiome in inflammatory bowel disease (IBD) is enriched in proinflammatory bacteria, yet defining a consistent dysbiotic signature is challenging, due to substantial variation between individuals and over time. We performed a high-resolution meta-analysis of 4...

Accurate MAG reconstruction from a complex soil microbiome through combined short- and HiFi long-reads metagenomics

Abstract Background Advances in high-fidelity long-read (HiFi-LR) sequencing technologies have opened new opportunities to explore the microbial genomic diversity of complex environments, such as soils. While short-read (SR) sequencing has enabled broad insights at the gene level...