Claudia Spies

Proteome signatures in ICU patients with COVID-19 and acute brain dysfunction: an observational cohort study

Abstract Deep sedation and delirium are common in COVID-19 intensive care unit (ICU) patients. Biomarkers for prediction, detection, and monitoring are missing. Unbiased omics analyses are warranted to gain a systems biology view on pathophysiology. This prospective observational...

Non-guideline—compliant prescriptions of benzodiazepines and Z drugs: Effects of social norm feedback. A randomized controlled trial

BACKGROUND: In Germany, long-term prescribing of benzodiazepines and Z drugs remains common even though their use for no more than 30 days is recommended in the guidelines because of risks including dependence, cognitive impairment, and falling. In this randomized controlled tria...

The impact of an intensive care telemedicine program on weaning from invasive ventilation: a secondary analysis of the ERIC trial

Abstract Background ICU patients commonly require invasive mechanical ventilation. Although weaning from ventilation is crucial for patient outcomes, it is commonly not performed according to guideline recommendations. We investigated if a complex telemedicine intervention improv...