Clarisa Parodi

Beyond Catalysis: Physiology, Cellular Biology And Therapeutic Strategies for Metallo-β-Lactamase-Producing Pathogens

Abstract Metallo-β-lactamases (MBLs) are zinc-dependent β-lactamases that threaten the clinical utility of carbapenems and other last-line β-lactams in Gram-negative pathogens. Their impact cannot be explained solely based on their catalytic efficiency. Clinically relevant MBLs d...