Chuwen Ma

A MAM-targeted integrated atomic-precision MnSe janus nanozyme platform inhibits pyroptosis and ferroptosis for intervertebral disc degeneration therapy

Aberrant endoplasmic reticulum (ER)–mitochondria crosstalk at mitochondria-associated ER membranes (MAMs) drives oxidative stress, calcium dysregulation, pyroptosis, and ferroptosis in nucleus pulposus cells, accelerating intervertebral disc degeneration (IVDD). Nanozymes that mi...