Chutima Thepparit

Sequence-Dependent PNA–AgNP Bioconjugation Enables Electrochemical Discrimination of a Single-Base Mutation in Zika Virus RNA

Abstract Single-nucleotide polymorphisms (SNPs) in RNA viruses such as Zika virus (ZIKV) can alter viral pathogenicity and are therefore critical molecular markers for surveillance. Here, we report an electrochemical hydrogel biosensor that discriminates a clinically relevant ZIK...