Chunhai Fan

Programming Hydrophobic Nanocavity of DNA Frameworks for Ultrastable Fluorescent Imaging

ABSTRACT Fluorescent proteins (FPs) are widely used in biological imaging, yet their limited programmability restricts adaptability for advanced nanoscale applications. Synthetic molecular containers offer designable cavities but struggle to simultaneously achieve large dimension...

A Self‐Propelled DNA‐Based Nanorobot for Hypoxic Tumor Therapy

ABSTRACT Solid tumors pose major therapeutic hurdles due to pathophysiological barriers such as hypoxia and dense stroma, which severely restrict drug penetration. Conventional nanomedicines lack the autonomous capability to navigate these evolving obstacles. Here, we engineer a...

Defect Engineering of DNA Origami ROS Sensors for Portable Urinalysis

ABSTRACT Translating in situ dynamic changes of key signaling molecules into actionable clinical readouts remains a formidable challenge for noninvasive diagnostics. Here, focusing on reactive oxygen species (ROS) as pivotal signaling mediators, we developed defect‐programmed DNA...