Chun-Sui Kwok

KDM2B controls HIF levels and activity through its JmjC and CxxC domains.

Hypoxia-inducible factors (HIFs) are key regulators of cellular responses to low oxygen (hypoxia), controlling the expression of genes required for survival and adaptation. KDM2B, a chromatin-modifying enzyme, is a direct target of HIF-1α, but its precise role in regulating HIF a...