Chulin Chen

Chronic BDE-47Exposure Induces DNA Damage in Hepatocytes:Involvement of Oxidative Stress and CYP1A1/2 Upregulation

Abstract 2,2′,4,4′-Tetrabromodiphenyl ether (BDE-47) is a persistent food-chain pollutant targeting the liver, whose genotoxic potential remains poorly understood. Here we investigated BDE-47-triggered DNA damage using HepG2 cells and C3H/He mice. BDE-47 exposure markedly elevate...