Chuanyu Liu

Multiomics profiling identifies molecular and cellular signatures of regular exercise in human peripheral blood

Regular exercise is well established to protect against metabolic disorders and bolster immunity, but the underlying molecular and cellular mechanisms remain incompletely understood. We integrated plasma metabolomics and lipidomics with single-cell transcriptomic and chromatin ac...

Complete genome-derived metabolic interactions reveal the impact of gut ecology on human health

Abstract Metabolic interactions govern gut microbiome assembly, yet functional rules remain obscured by genomic incompleteness and fragmentation. Here, we leverage 1,150 complete genomes to construct genome-scale metabolic models, demonstrating that draft genomes introduce system...