Chuanhong Wu

Stable truncating mutations in plakophilin-2 induce arrhythmogenic cardiomyopathy-like phenotypes in adult zebrafish

Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiac disorder characterized by arrhythmias and fibrofatty myocardial remodeling, often leading to heart failure and sudden cardiac death. Mutations in plakophilin-2 ( PKP2 ) represent the most prevalent genetic cause of ACM....