Chuanguang Xiao

Chaperone-mediated autophagy as a context-resolved proteostatic decision node in breast cancer

Therapy resistance, metastatic relapse, and immune evasion are major contributors to breast cancer–related mortality; however, the proteostatic systems that support phenotypic plasticity remain incompletely understood. Chaperone-mediated autophagy (CMA) is a selective lysosomal p...