Christopher R. Flowers

Key Challenges on the Path toward Precision Immunotherapy for Large B-cell Lymphoma

Summary: Cell and immune therapies have transformed the outcomes of patients with lymphoma, but the majority of patients do not have durable benefit. Here, we provide our perspective on key challenges in personalizing cell and immune therapy approaches for lymphoma through discov...

Evaluation of gene expression assays to classify large B-cell lymphoma by molecular subtype using formalin-fixed paraffin-embedded tumor biopsies

Gene expression profiling (GEP) can classify large B-cell lymphoma (LBCL) into activated B-cell (ABC), dark zone signature (DZsig), and germinal center B-cell (GCB) subtypes, which can inform prognosis and treatment strategies. We evaluated the concordance of Clinical Laboratory...