Christopher L. Berger

Tau hyperphosphorylation impairs cooperative binding to microtubules and perturbs organelle trafficking in neurons

Tau, a neuronal microtubule-associated protein (MAP), organizes the axonal cytoskeleton, and regulates intracellular transport. Tau hyperphosphorylation is linked to neurodegeneration in tauopathies, including Alzheimer’s disease. Tau binds microtubules cooperatively to form cohe...