Christopher Gerner

Shear stress alters mito-cytoskeletal dynamics and mobilizes mechanosensitive transcription factors supporting a chemoresistant phenotype in ovarian cancer cells

Abstract Ovarian cancer remains one of the most lethal gynecological malignancies, largely due to the frequent development of resistance to platinum-based chemotherapies such as cisplatin (cisPt). Emerging evidence supports that the biophysical properties of the tumor microenviro...