Christopher Beeghly

sGC oxidation impairs NO-dependent ophthalmic artery vascular reactivity and alters long-term memory performance in mice

Nitric oxide (NO)-dependent activation of soluble guanylyl cyclase (sGC) is essential for maintaining cerebrovascular function and cognitive processes. However, sGC is susceptible to oxidative inactivation under vascular and neurodegenerative stress. This study investigated the i...