Christopher A. Ovens

Quantifying mitochondrial stress in LHON patients – an exploratory study of flavoprotein autofluorescence

Abstract Purpose Leber Hereditary Optic Neuropathy (LHON) is a primary mitochondrial disorder, where retinal ganglion cell dysfunction typically leads to sequential blindness. Although targeted gene therapies have shown promise, clinical trials have struggled to show efficacy usi...