Christoph Kleinschnitz

The kallikrein-kinin system modulates CD4+ T cell function and contributes to T cell migration into the brain after stroke

Abstract Ischemic stroke elicits a sustained thromboinflammatory response that critically shapes secondary brain injury. The kallikrein-kinin system (KKS) has been identified as the interface of vascular injury and inflammatory processes; however, its role in adaptive immunity re...

Real-world short-term effectiveness of erenumab after single versus multiple prior preventive treatment failures

BACKGROUND: Erenumab, a monoclonal antibody targeting calcitonin gene-related peptide receptor, has been approved in Germany since 2018 for migraine prophylaxis. Initially, reimbursement regulations restricted its use to drug-resistant patients who had failed or were unsuitable f...