Christoforos G. Kokotos

A Green Protocol for the Deprotection of ortho ‐Nitrobenzyl Esters and Ethers by UVA–LED Irradiation

ABSTRACT The removal of protecting groups in synthetic organic transformations under green and mild conditions is of high interest. In this study, a green photochemical protocol for the deprotection of ortho ‐nitrobenzyl esters and ethers is introduced, utilizing LED 370 nm irrad...

Machine Learning-Guided Discovery of Robust Conditions for Photochemical Nickel-Catalyzed Cysteine Arylation

Abstract Late-stage functionalization (LSF) of peptides offers direct access to structurally diverse analogues, but developing general, chemoselective protocols remains challenging due to the complexity of peptide substrates and the vast number of reaction variables. Traditional...

Metal‐Free Decarboxylative Allylation of N‐Protected Amino Acids and Carboxylic Acids via Thioxanthone Photocatalysis

ABSTRACT In response to the growing demand for efficient synthetic methodologies, we report herein a practical and cost‐effective photochemical decarboxylative allylation protocol, utilizing thioxanthone as an affordable organic photocatalyst under blue‐LED irradiation. This meta...

Visible‐Light‐Mediated Synthesis of Biscoumarins Utilizing Photocaged Sulfonic Acid as the Catalyst

Throughout the years, biscoumarin derivatives, known for their diverse biological properties, have attracted extensive synthetic interest. In pursuit of a sustainable, versatile, and cost‐effective protocol, we studied the reaction between 4‐hydroxycoumarin and various aldehydes,...