Christof Maria Kramm

Limited evidence for chemo- and radiosensitization by HDAC inhibitors in gliomasphere models of pediatric high-grade glioma

Abstract Purpose Pediatric high-grade glioma (pedHGG), including diffuse intrinsic pontine glioma (DIPG) and non-pontine diffuse midline glioma, remains uniformly lethal despite radiotherapy and, in some protocols, temozolomide (TMZ). Recurrent histone H3 mutations reducing H3K27...