Christof Lenz

MDM2 binds and suppresses RNA polymerase III to restrain the innate immune response to cytosolic DNA

Abstract The oncoprotein MDM2 is widely recognized as the principal negative regulator of p53, thereby controlling the expression of numerous RNA polymerase II (Pol II)-dependent genes involved in cell cycle arrest and apoptosis. Beyond this canonical role, MDM2 also engages in t...