Christian H. Bucher

The cortical microenvironment drives early immune organization and controls early osteoclastogenesis in bone healing

Abstract Bone regeneration is a complex, tightly-regulated process involving coordinated interactions of immune and stromal cells. Early phases of healing rely on the timely clearance of debris, a task primarily carried out by macrophages and osteoclasts. However, the sequence of...

The importance of B cells for osteogenic homeostasis

Abstract Therapeutic interventions for diseases such as leukemia and autoimmune disorders are increasingly designed to selectively target and deplete specific immune cell subsets over prolonged periods. This can disrupt the homeostasis of the adaptive immune system, with conseque...