Chinmai Rayidi

Structure-based identification of a membrane-retained OmpA candidate against Acinetobacter baumannii by membrane molecular dynamics and phenotypic antibacterial assessment

Outer membrane protein A (OmpA) contributes to the envelope integrity and virulence of Acinetobacter baumannii and contains a lumenal cavity that may accommodate small molecules. We screened 99,878 ChEMBL-derived compounds against a structural model of the OmpA transmembrane barr...