Chin-Chin Ho

Real-world implementation and evaluation of a pharmacogenomic clinical decision support system for allopurinol and HLA-B*58:01

Abstract Background Allopurinol-induced severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), are strongly associated with the HLA-B*58:01 allele. Despite guidelines recommending genotyping prior to initiation,...