Chikao Onogi

Kidney dysfunction under cardiometabolic stress promotes calorie-intake-independent wasting and frailty-like muscle phenotypes

Although age-related sarcopenia and frailty are linked to impaired metabolic flexibility and disrupted energy homeostasis, whether this framework explains chronic kidney disease (CKD)-related wasting remains unclear. We show that superimposed nephron loss redirects cardiometaboli...