Chihiro Akazawa

Sensory nerves regulate bone homeostasis in response to mechanical unloading or reloading: evidence from a spaceflight experiment and ground-based mechanical unloading models

Mechanical loading is crucial for maintaining bone mass, and understanding how bone remodels in response to mechanical loading is essential for treating musculoskeletal disorders. Recently, sensory nerves inside bone were identified as mechanical regulators of bone homeostasis. H...

Leveraging the salivary microbiome profile to stratify REM sleep behavior disorder and synucleinopathies

Abstract Few studies have explored noninvasive biomarkers of synucleinopathies, including Parkinson’s disease (PD), and rapid-eye-movement behavior disorder (RBD), a prodromal stage for these conditions. Human oral/salivary microbiomes are altered in PD, highlighting their potent...