Chien-Han Kao

Notch-hedgehog antagonism regulates stem cell niche formation through an E2-E3-E3 ubiquitin module

Abstract Distinct microenvironments, including the stem cell niche and differentiation zone, promote stem cell self-renewal and progeny differentiation, yet how these domains are established remains unclear. In the developing Drosophila ovary, we show that Notch activation silenc...