Chiaki Mashima

Potential of β-catenin inhibitors as a novel therapeutic strategy for PIK3CA/CTNNB1 double-mutant endometrial cancer

Abstract Endometrial cancer (EC) is one of the most prevalent gynecological malignancies. EC is characterized by limited therapeutic options and a substantial unmet medical need, particularly in advanced or metastatic stages. Although a high prevalence of concurrent PIK3CA and CT...