Chenying Zhang

Integrative genomic and functional analysis identifies BCL10 as a novel driver of trophoblast senescence in preeclampsia

OBJECTIVE: To identify senescence-driving genes causally linked to preeclampsia (PE) and to elucidate impact on placental dysfunction. METHODS: Placental RNA-seq data set GSE234729 was analyzed for differentially expressed genes. Weighted gene co-expression network analysis was u...

RUNX2 promotes osteoclast differentiation and bone resorption via the newly identified LncRNA-ROD: implications for alveolar remodeling

Abstract Delayed tooth eruption is a hallmark of cleidocranial dysplasia (CCD) caused by RUNX2 haploinsufficiency, yet the underlying molecular mechanism remains undefined. Here, we show that RUNX2 regulates osteoclast-mediated alveolar bone remodeling, a process closely associat...