Chenshuang Dong

MORC2-Mediated Glutamine Metabolic Remodeling Regulates Tumor-Associated Macrophage Function and Immunotherapeutic Responses in NSCLC

Non-small cell lung cancer (NSCLC) frequently exhibits primary or acquired resistance to PD-1/PD-L1 blockade, partly because of the immunosuppressive tumor microenvironment. Tumor-associated macrophages (TAMs) are a major immune-cell population in NSCLC and contribute to tumor pr...