Chengsheng Zhang

A nationwide study of pathogens in hospitalized patients with lower respiratory tract infections by metagenomic next-generation sequencing

ABSTRACT Lower respiratory tract infections remain a major cause of morbidity and mortality, yet timely etiologic diagnosis is difficult because of the breadth of possible pathogens and the limitations of conventional microbiological tests. We retrospectively analyzed 30,819 clin...

Association of neoadjuvant subcutaneous trastuzumab with higher pathological complete response in HER2-positive breast cancer: a real-world doubly robust study

Randomized trials have demonstrated the non-inferiority of subcutaneous (SC) versus intravenous (IV) trastuzumab. Its association with pathological complete response (pCR) in routine neoadjuvant practice warrants further study. The ability of serial ultrasound measurements to dis...