Chengdong Chang

NF-κB/Lipocalin 2 Signaling Pathway Mitigates the Chemoresistance of BRAFV600E-Mutant Colorectal Cancer to Cisplatin by Promoting Ferroptosis

Background: Colorectal cancers (CRCs) harboring the BRAFV600E (V600E) mutation exhibit aggressive clinical behavior and chemotherapy resistance, yet the underlying mechanisms remain poorly understood. Ferroptosis, which is driven by iron-dependent lipid peroxidation, has emerged...