Chen Yan

Metabolic-epigenetic nanoregulator attenuates a folate-deficiency-associated senescence phenotype in intervertebral disc degeneration

Intervertebral disc degeneration (IVDD) is increasingly recognized as an aging-associated disorder driven in part by nucleus pulposus cell (NPC) senescence, yet the nutrient-sensitive metabolic defects that sustain this state remain poorly understood. Here, we investigated impair...