Chen Liu

Mitochondria-Targeted Prodrug Nanoassemblies Elicit Antitumor Immunity via Mitophagy-Boosted Ferroptosis in Triple-Negative Breast Cancer

Abstract Ferroptosis, an immunogenic iron-dependent cell death driven by lipid peroxidation, holds promise for treating triple-negative breast cancer (TNBC). However, its efficacy is severely compromised by restricted iron availability and the potent GPX4/GSH defense system. Here...

Aqueous extract of Nasturtium officinale: a potential therapeutic approach to be explored in the fight against multidrug-resistant Pseudomonas aeruginosa

The rise in global bacterial resistance has made the development of new therapies an urgent challenge, positioning Pseudomonas aeruginosa as a critical priority pathogen. In this context, phytotherapy stands out due to the wide diversity of bioactive compounds with antimicrobial...

Convergent use of aminopeptidase N receptor by hedgehog merbecoviruses

Abstract Coronaviruses circulating in wildlife, such as European and Asian hedgehog merbecoviruses (EriCoVs), pose a potential transmission risk. Knowledge of viral receptors can inform risk assessment and development of countermeasures; however, the functional receptor for EriCo...