Chen Dong

Dynamic expression of IL-21 in effector CD8 T cells helps control chronic infections

CD8 T cells are critical players in immune responses against pathogens. Interleukin-21 (IL-21) is predominantly produced by CD4 T cells and exerts multifaceted effects on CD8 T cell regulation and function. Using Il21 -reporter and Il21 –fate mapping mice, we report that a subpop...