Changyou Zhan

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

ABSTRACT The immunosuppressive microenvironment limits immunotherapy in triple‐negative breast cancer (TNBC). Interleukin‐15 (IL‐15) activates cytotoxic lymphocytes but is limited by rapid clearance and poor tumor retention. Here, we developed an oncolytic adenovirus encoding IL1...