Changjiang Dong

Structural and Mechanistic Insights Into GSDME Pore Formation and Functional Regulation

ABSTRACT Gasdermin E (GSDME) is a unique member of the gasdermin family linked to deafness, cancer, and neurodegenerative diseases, and mediates chemotherapy‐induced pyroptosis; however, its pore‐forming mechanism remains poorly understood. Here, we present cryo‐EM structures of...