Author
Changhan Lee
Recent research
- BiologyOpen access
pH‐Driven Two‐Stage Conformational Switching Activates an Acid‐Responsive Chaperone
ABSTRACT Acidification rapidly denatures bacterial periplasmic proteins, yet this compartment lacks ATP‐dependent chaperones. We identify AchC as an acid‐responsive, ATP‐independent chaperone crucial for acid tolerance in Pseudomonas aeruginosa . As proton influx across the outer...
- BiologyOpen access
pH‐Driven Two‐Stage Conformational Switching Activates an Acid‐Responsive Chaperone
ABSTRACT Acidification rapidly denatures bacterial periplasmic proteins, yet this compartment lacks ATP‐dependent chaperones. We identify AchC as an acid‐responsive, ATP‐independent chaperone crucial for acid tolerance in Pseudomonas aeruginosa . As proton influx across the outer...