Chang Min

Controlled Epoxide-Enabled Formal Oxygen Insertion of Indenones to Isocoumarins

Abstract Regioselective oxygen insertion into sp2-rich carbonyl scaffolds remains challenging because Baeyer–Villiger oxidation relies on migratory aptitude. Here, we translate an aziridine-based nitrogen-insertion platform to an epoxide-enabled oxygen-insertion manifold for inde...

A Selective ERα Photodegrader for Precise and Efficient Breast Cancer Treatment

Abstract Breast cancer is the most prevalent malignancy in women, with over 70% of cases being estrogen receptor α (ERα)-positive. Photodynamic therapy (PDT) is spatially precise yet limited by tumor-selective photosensitizers. Herein, we report the first co-crystal structure of...