Chang Li

Two-stage management of traumatic comminuted trapezium fracture with severe bone defect: a case report and literature review

Trapezium fractures are rare carpal injuries, and comminuted intra-articular patterns with severe bone loss are exceptionally uncommon and challenging, with no established consensus; patient-specific 3D printing may offer a reconstructive option. We report a 51-year-old man who s...

Acupuncture alleviates the progression of lumbar disc herniation by regulating the autophagy level of nucleus pulposus cells through the SIRT1/Sestrin2 pathway.

BACKGROUND AND PURPOSE: Lumbar disc herniation (LDH) is a degenerative spine disease and the most common cause of lower back pain, with a high prevalence in younger patients. The use of acupuncture (AC) as a conservative treatment for LDH has received widespread attention at home...

IL-1α and CRP as key inflammatory mediators linking neuropathic pain, anxiety, and depression in major depressive disorder

<title>Abstract</title> <bold>Background:</bold> It’s common comorbidity for Major Depressive Disorder (MDD), anxiety, and pain, underpinned by shared chronic inflammatory processes, this study aimed to identify etiological inflammatory biomarkers, focusing on MDD individuals wit...