Catigan Hedican

A CD40-Targeted IL-21 fusokine enables rapid generation of human IL-10⁺granzyme B⁺ regulatory B cells

Regulatory B cells (Bregs) suppress pathogenic immune responses and maintain immune homeostasis, but their rarity and poor ex vivo expandability limit clinical translation as cellular therapeutics. Here, we describe a feeder-free platform for rapid generation of human IL-10⁺Granz...