Catherijne A. J. Knibbe

The influence of heteroresistance, growth and antibiotic selection in shaping the invasion dynamics of colistin resistant Pseudomonas aeruginosa

Abstract Heteroresistance, where a small subpopulation of resistant cells coexists within an otherwise susceptible population, plays a critical role in bacterial survival during antibiotic exposure. Yet, its influence on the invasion success of resistant strains remains poorly un...

A mechanism-based model of immune status effects on antibiotic PK/PD targets in bacteremia

Abstract A key determinant of antibiotic dose selection is the pharmacokinetic/pharmacodynamic (PK/PD) target, typically determined using dose fractionation studies in preclinical infection models. However, such studies often do not consider the host immune response, despite its...